Figure 1.
Transgene expression of 4R‐tau in P301S results in increased total tau levels. A. Scheme of MoPrP‐hTau.P301S transgene. The mouse prion promoter (MoPrP) drives expression of the human tau isoform 1N4R, with one N‐terminal insert and four tubulin binding repeats harboring the P301S FTLD‐tau mutation. B. Western blot detection of total tau levels with Tau5 antibody in homogenates from cortex, hippocampus and striatum of P301S mice compared to WT animals at 20 weeks of age (n = 3; Student's t‐test, ** P < 0.01, ***P < 0.001).