Table 2.
Structure activity relationships of PS ASO-RNA and PS-ASO protein interactions
| PS ASO | Protein |
|---|---|
| ✓ Phosphorothioates | ✓ Domains (for key proteins) |
| o Number | ✓ Structures |
| o Placement | ✓ Charge |
| ✓ Charge | ✓ Hydrophobicity |
| ✓ 2′ modifications | ▪ Modifications |
| o Hydrophobicity | ▪ Acylation |
| o Number | ▪ Mesylation |
| o Orientation (5′ or 3′) | ▪ Phosphorylation |
| ▪ Sequence | ▪ Glycosylation |
| ✓ Base modifications | ▪ Lipidation |
| ▪ Pendant groups (conjugates) | ▪ Ubiquitinylation |
✓ More solid knowledge.
▪ Less knowledge.