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. 2021 Feb 22;2(3):100207. doi: 10.1016/j.xcrm.2021.100207

Figure 5.

Figure 5

cTfh cell responses and parameters of Th1:Th2 skew correlate with key markers of humoral immunogenicity

(A–C) Spearman correlation analyses were performed to interrogate the relationships between the frequency of PfRH5-specific cTfh cells at day 14 and the frequency of IgG+ mBCs that were PfRH5 specific at day 140 (A), the serum anti-PfRH5 IgG concentration at day 84 (B), and the purified IgG GIA at 10 mg/mL at day 70 (C).

(D–H) Spearman correlation analyses were also performed between the frequency of Th2 (CXCR3−CCR6−) (D) or Th1 (CXCR3+CCR6−) (E) cells within PfRH5-specific CD45RO+CD4+ T cells at day 14 and serum anti-PfRH5 IgG concentration at day 84, as well as between the IFN-γ:IL-5 ratio in day 63 supernatants and the frequency of IgG+ mBCs that were PfRH5 specific at day 140 (F), serum anti-PfRH5 IgG concentration at day 84 (G), and the purified IgG GIA at 10 mg/mL at day 70 (H).

Sample sizes, Spearman r, and p values annotated on the graphs refer to analyses of pooled samples from both vaccine platforms. In all of the panels, each point represents a vaccinee.