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. Author manuscript; available in PMC: 2021 Mar 10.
Published in final edited form as: Cell Metab. 2019 May 16;30(1):67–77.e3. doi: 10.1016/j.cmet.2019.05.008

Figure 1. Overview of the study design.

Figure 1.

Twenty adults were confined to the metabolic ward at the NIH Clinical Center. Every week, subjects spent one day residing in a respiratory chamber to measure energy expenditure, respiratory quotient, and sleeping energy expenditure. Average energy expenditure during each diet period was measured by the doubly labeled water (DLW) method. Body composition was measured by dual-energy X-ray absorptiometry (DXA) and liver fat was measured by magnetic resonance imaging/spectroscopy (MRI/MRS).