Skip to main content
. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Biochim Biophys Acta Rev Cancer. 2020 Nov 4;1875(1):188464. doi: 10.1016/j.bbcan.2020.188464

Figure 3: Role of glycosylation in cell-cell and cell-matrix interaction.

Figure 3:

In healthy cells, E-cadherin functions as a critical hemophilic cell-cell adhesion molecule. In tumor cells, aberrantly glycosylated tight junction and adherence proteins activate Wnt and FAK signaling cascades that promote transcription of targeted genes responsible for tumor cell migration and proliferation. Heavily glycosylated integrins interact with ECM proteins with the help of galectins that trigger various signaling pathways to promote migration, invasion, and proliferation in tumor cells.