Table 1. BioPAN predicted genes of the lipid active reactions in liver of aged vs young mice.
Table contains the active reactions chains found by BioPAN according to the Z-score values. Several genes are predicted as being involved in the current status of each reaction based on their function. Pathway options: aged condition of interest, young control condition, lipid type, active status, subclass level, reaction subset of lipid data, p value 0.05, no paired-data.
| lipid subclass active reaction (Aged vs Young) | ||
|---|---|---|
| Reaction chains | Z-score | Predicted genes |
| PE→PC→PS→LPS | 3.978 | PEMT, PTDSS1, PLA2G2E, PLA2G2A, PLA2G2F |
| DG→PC→PS→LPS | 3.686 | CHPT1, PTDSS1, PLA2G2E, PLA2G2A, PLA2G2F |
| PE→PC→LPC | 3.519 | PEMT, PLA2G2E, PLA2G2A, PLA2G2D, PLA2G2F, PLA2G1B |
| LPA→PA→PG→LPG | 3.367 |
AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT5, CDS1, CDS2, PTPMT1, PLA2G4D, PLA2G4F,
CRLS1 |
| PE→PC→PA→PG→LPG | 3.179 | PEMT, PLD1, PLD2, CDS1, CDS2, PTPMT1, PLA2G4D, PLA2G4F, CRLS1 |
| DG→PC→LPC | 3.161 | CHPT1, PLA2G2E, PLA2G2A, PLA2G2D, PLA2G2F, PLA2G1B |
| PG→LPG | 3.077 | PLA2G4D, PLA2G4F, CRLS1 |
| LPA→PA→PS→LPS | 2.898 | AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT5, CDS1, PTDSS1, PLA2G2E, PLA2G2A, PLA2G2F |
| DG→PE→LPE | 2.815 | CEPT1, PLA2G4C |
| PE→PS | 2.700 | PTDSS2 |
| PC→PS→LPS | 2.657 | PTDSS1, PLA2G2E, PLA2G2A, PLA2G2F |
| DG→MG | 2.507 | PNPLA2, PNPLA3 |
| DG→TG | 2.301 | DGAT2 |
| DG→PC→PA | 2.280 | CHPT1, PLD1, PLD2 |
| dhSM→dhCer→Cer→Cer1P | 2.218 | SGMS1, SGMS2, DEGS1, DEGS2, CERK |
| DG→PA | 2.050 | DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKK, DGKQ, DGKZ |
| O-PE→O-LPE | 1.942 | PLA2G4A |
| LPA→PA→PI | 1.878 | AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT5, CDS1, CDS2, CDIPT |
| PC→LPC | 1.843 | PLA2G2E, PLA2G2A, PLA2G2D, PLA2G2F, PLA2G1B |
| PE→PC→PA→PI | 1.837 | PEMT, PLD1, PLD2, CDS1, CDS2, CDIPT |
| PS→LPS | 1.668 | PLA2G2E, PLA2G2A, PLA2G2F |
| PE→PC→CL | 1.667 | PEMT, TAZ |