Figure 8.
HFrD-induced worsening of colitis is transferrable through gut luminal content. Cecal content and feces were transferred from mice fed control diet or HFrD for 1 week (n = 5/group) to GF mice fed control diet. Recipient mice in both groups were fed control diet after the inoculation. Measurements of colitis severity including diarrhea (A), bleeding (B), colon length (C), and colonic ulceration (D) were made during DSS administration (A and B) or at end of the study (C and D). Data are presented as mean ± standard deviation (N = 5–6/group). Data were generated from a single experiment.