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. 2021 Jan 1;11(4):1937–1952. doi: 10.7150/thno.45511

Figure 8.

Figure 8

Involvement of ferroptosis in the Mn-MOF-induced improved tumor immunity. (A-I) The numbers of CD4+ T cells (A), CD8+ T cells (B), CD8+CD69+ T cells (C), CD8+IFN-γ+ T cells (D), CD8+GzmB+ T cells (E), CD11c+CD80+ dendritic cells (F), CD11c+CD86+ dendritic cells (G), MDSCs (H) and Tregs (I) in tumor tissues of H22 tumor-bearing mice after intravenous injection of PBS, Mn-TCPP, MOF or Mn-MOF at Zr dosage of 5 mg/kg (the corresponding Mn dosage was 1 mg/kg) in the presence or absence of intraperitoneal injection of UAMC-3203 at 20 μg/kg dosage, followed by US irradiation (1.0 MHz, 1 W/cm2, 50% duty cycle) at tumors for 10 min. The data are presented as mean ± s.d. (n= 5). *P < 0.05, **P < 0.01, ***P < 0.001.