Figure 7.
In vivo SDT effects of Mn-MOF in metastatic 4T1 tumor-bearing mice. (A) Tumor growth curves of 4T1 tumor-bearing mice after intravenous injection of PBS, Mn-TCPP, MOF or Mn-MOF at the Zr dosage of 5 mg/kg and Mn dosage of 1 mg/kg, followed by US irradiation (1 MHz, 1.0 W/cm2, 50% duty cycle) for 5 min. The data are presented as mean ± s.d. (n= 13). (B) Tumor weight at the end of treatment indicated in A. The data are presented as mean ± s.d. (n= 5). (C) Kaplan-Meier survival plot of 4T1 tumor-bearing mice after treatment indicated in A (n= 8). (D,E) Immunofluorescent staining of CD31-labeled vessels (D) and HIF-1α (E) in tumor tissues of mice after treatment indicated in A. Scale bar: 50 μm. (F,G) Pulmonary metastatic nodules (F) and lung weight (G) in 4T1 tumor-bearing mice after treatment indicated in A. The data are presented as mean ± s.d. (n= 5). *P < 0.05, **P < 0.01, ***P < 0.001.