Figure 1.
Genome-wide SHAPE-MaP analysis of SARS-CoV-2. (A) Heat scatter plot of normalized reactivities across two biological replicates for the in vitro SHAPE (left) and DMS (center) datasets, and the in vivo SHAPE dataset (right). (B) Normalized in vivo SHAPE reactivities superimposed on the 5′ UTR structure. Highly (red) and moderately (yellow) reactive residues from in vitro SHAPE (circles) and DMS (triangles) experiments are also indicated. A novel putative stem-loop 8 (pSL8), coherently predicted in all our datasets is also reported.