Figure 4. Computational simulations of receptor assembly.
a, Schematic diagram of the simulation process. b, Expression of selected GABAAR subtypes across different simulated conditions. Out of all conditions that favour the expression patterns observed in experimental data from α4β3δ (top) or α4β3γ2 cell line (bottom) (Methods), twenty examples were randomly chosen for display. Here x denotes δ (top) or γ (bottom). Each row represents one simulated condition. The colour scale indicates subtype abundance in each condition. Receptor subtypes expressed across different simulated conditions are shown between the two panels. Experimentally observed subtypes are denoted with dashed boxes (red and blue for α4β3δ and α4β3γ2, respectively).