Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 16;8(2):e001054. doi: 10.1136/jitc-2020-001054

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Intratumoral NK cells phenotype and cytokine secretion. (A) Eomes, NKG2A, CD69, NKp44, CD107a, FS7-associated cell surface antigen (FAS), C-X-C chemokine receptor type 6 (CXCR6), CX3CR1 and sphingosine-1-phosphate receptor 1 (S1PR1) protein expression were analyzed in natural killer (NK) cells (CD3⁻CD56⁺) by flow cytometry after cell surface staining of cells from non-tumorous (Non-Tum) or tumorous (Tum) tissue of patients with non-small cell lung carcinoma. Percentages or GeoMean is presented. (B) Co-staining for NKp46/Eomes, NKp46/cytotoxic T-lymphocyte-associated protein 4 (CTLA4) and CTLA4/NKG2A is shown on CD3⁻CD56⁺ intratumoral NK cells. (C) Quantification of cytokines produced by NK cells sorted from Tum or Non-Tum tissue. Statistical analyses were performed by Wilcoxon method with the GraphPad software. ns: not significant. *p<0.05; **p<0.01; ***p<0.001; p<0.0001.