TABLE 4.
Gene sets enrichment of low METTL16 mRNA expression level in the TCGA HCC dataset.
| KEGG Pathways | ES | NES | Nominal P-value | FDR q-value |
| KEGG_PEROXISOME | −0.70 | −2.04 | < 0.001 | 0.044 |
| KEGG_DRUG_METABOLISM_OTHER_ENZYMES | −0.81 | −1.86 | < 0.001 | 0.062 |
| KEGG_PPAR_SIGNALING_PATHWAY | −0.65 | −1.85 | 0.002 | 0.055 |
| KEGG_STEROID_HORMONE_BIOSYNTHESIS | −0.77 | −1.73 | 0.004 | 0.110 |
| KEGG_DRUG_METABOLISM_CYTOCHROME_P450 | −0.78 | −1.72 | < 0.001 | 0.087 |
| KEGG_GLYCOLYSIS_GLUCONEOGENESIS | −0.54 | −1.70 | 0.002 | 0.076 |
ES, Enrichment Score; NES, Normalized Enrichment Score. The NES is the enrichment score for the gene set after it has been normalized by gene numbers. The NES is calculated by dividing the actual ES score by the mean ES of all random combinations of gene sets.