TABLE 1.
The CNV patterns of m6A regulatory genes in HCC samples (n = 370).
| Diploid | Deep deletion | Shallow deletion | Copy number gain | Amplification | CNV sum | Percentage | ||
| Writer | METTL3 | 252 | 78 | 37 | 3 | 118 | 31.89% | |
| METTL14 | 199 | 1 | 160 | 10 | 171 | 46.21% | ||
| METTL16 | 140 | 8 | 203 | 19 | 230 | 62.16% | ||
| WTAP | 190 | 7 | 132 | 40 | 1 | 180 | 48.65% | |
| KIAA1429 | 134 | 1 | 15 | 168 | 52 | 236 | 63.78% | |
| ZC3H13 | 179 | 8 | 170 | 13 | 191 | 51.62% | ||
| RBM15 | 231 | 86 | 51 | 2 | 139 | 37.57% | ||
| Eraser | ALKBH5 | 172 | 4 | 156 | 35 | 3 | 198 | 53.51% |
| FTO | 202 | 4 | 143 | 21 | 168 | 45.41% | ||
| Reader | YTHDF1 | 236 | 8 | 119 | 7 | 134 | 36.22% | |
| YTHDF2 | 209 | 4 | 136 | 21 | 161 | 43.51% | ||
| YTHDF3 | 150 | 30 | 159 | 31 | 220 | 59.46% | ||
| YTHDC1 | 207 | 146 | 13 | 4 | 163 | 44.05% | ||
| YTHDC2 | 209 | 46 | 112 | 3 | 161 | 43.51% | ||
| IGF2BP1 | 234 | 27 | 102 | 7 | 136 | 36.76% | ||
| IGF2BP2 | 267 | 43 | 52 | 8 | 103 | 27.84% | ||
| IGF2BP3 | 233 | 16 | 116 | 5 | 137 | 37.03% | ||
| HNRNPA2B1 | 237 | 16 | 113 | 4 | 133 | 35.95% | ||
| HNRNPC | 250 | 79 | 36 | 5 | 120 | 32.43% | ||
| TP53 | 132 | 9 | 216 | 13 | 238 | 64.32% |
The CNV status was defined by GISTIC, including Deep deletion (homozygous deletion), Shallow deletion (heterozygous deletion), Diploid (normal copy number), Copy number gain (low level gain), and Amplification (high level amplification).