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. 2020 Aug 3;75(11):3269–3277. doi: 10.1093/jac/dkaa310

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© The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Schematic of the final clofazimine population PK model. The dose is assumed to go through a series of transit compartments, where NN describes the number of transit compartments and the transit rate constant (Ktr) the transfer rate, calculated as NN + 1 divided by the mean transit time (MTT). Drug is then absorbed into the central compartment (representing the plasma concentration of clofazimine), described by the absorption rate constant (Ka). Bidirectional equilibration (Q1 and Q2) occurs with two peripheral tissue compartments, deep (V_p1) and shallow (V_p2), while drug is eliminated from the central compartment with first-order kinetics (CL). Cmpt, compartment. This figure appears in colour in the online version of JAC and in black and white in the print version of JAC.