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. 2020 Oct 15;17:305. doi: 10.1186/s12974-020-01967-2

Table 1.

The effects of FTS•B on cytokines levels in the serum of APP/PS1 mice

WT APP/PS1
FTS•B (mg/kg)
10 40
TLR3 (ng/mL) 29.6 ± 1.6 21.7 ± 1.9## 27.3 ± 1.7* 29.8 ± 1.2**
p-IRF3/IRF3 1.2 ± 0.1 0.8 ± 0.0## 0.9 ± 0.1* 0.9 ± 0.0*
IFN-β (pg/mL) 95.4 ± 7.0 51.5 ± 7.2### 89.8 ± 15.4* 90.7 ± 6.3***
JIP3 (ng/L) 233.9 ± 41.7 379 ± 35.9## 274.7 ± 57 219.9 ± 40.9**
p-JNK/JNK 5.3 ± 0.6 8.4 ± 1.0## 5.3 ± 0.8* 5.4 ± 0.6*
p-APP/APP 0.2 ± 0.0 0.4 ± 0.1## 0.2 ± 0.1** 0.3 ± 0.1**
Aβ (mg/L) 2.5 ± 0.2 3.0 ± 0.1# 2.4 ± 0.2** 2.3 ± 0.2**
TNF-α (ng/L) 132.6 ± 13.2 189.7 ± 22.6# 101.5 ± 25.3** 103 ± 17.7**
IL-1β (ng/L) 91 ± 6.1 124.9 ± 8.9# 95.9 ± 4.9** 87.8 ± 7.6**
IL-6 (pg/mL) 193.1 ± 8.9 223.7 ± 7.8# 190.2 ± 7.5** 177.9 ± 11.9**
IL-8 (pg/mL) 367.3 ± 23.2 471.8 ± 22.9## 364.1 ± 37.8* 310.3 ± 22.9***
IL-12 (ng/L) 58.6 ± 6.5 82.3 ± 4.0## 69.5 ± 3.5* 67.2 ± 2.9*

Data are expressed as the mean ± standard error (n = 8)

#p < 0.05

##p < 0.01

###p < 0.001 vs. WT mice

*p < 0.05

**p < 0.01

***p < 0.001 vs. APP/PS1 mice