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. Author manuscript; available in PMC: 2020 Dec 29.
Published in final edited form as: Nat Genet. 2020 Jun 29;52(9):939–949. doi: 10.1038/s41588-020-0644-z

Fig. 6: m6A-TWAS and colocalization analysis.

Fig. 6:

a, Number of significant m6A-TWAS genes in selected immune and blood-related traits. b, Overlaps between significant genes discovered by TWAS analyses using m6A, expression and splicing as molecular-level phenotypes. c, Manhattan plot of m6A-TWAS associations of lymphocyte count. The dashed line shows the Bonferroni-corrected P value threshold of 0.05. Genes are colored by Coloc PP.4 (posterior probability of GWAS trait and m6A-QTL sharing common genetic causal variants). 10 genes with Coloc PP.4 > 0.5 are labeled. d, Aligned Manhattan plots of GWAS and m6A-QTL at DDX55 locus generated by LocusCompare. SNPs are colored by LD (r2) with the lead m6A-QTL (rs3204541). e, Manhattan plot of GWAS association signal of lymphocyte count at DDX55 locus before (gray dots) and after (blue dots) conditioning on the TWAS-predicted m6A level. The top panel labels all genes within 200 kb and the significant m6A peak (green).