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. 2020 Aug 16;8(2):e000978. doi: 10.1136/jitc-2020-000978

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Intratumoral TIGIT⁺ CD8⁺ T-cell infiltration impairs CD8⁺ T-cell antitumor immunity in patients with muscle-invasive bladder cancer. (A) Expression of coinhibitory receptors (PD-1, n=24; CTLA-4, n=16; Tim-3, n=14; Lag-3, n=17) on CD8⁺ T-cells in TIGIT⁺ CD8⁺ T-cells high/low infiltration group. (B) Expression of proliferation marker (Ki-67, n=16) on CD8⁺ T-cells in TIGIT⁺ CD8⁺ T-cells high/low infiltration group. (C) Expression of effector cytokines (IFN-γ, n=23; TNF-α, n=23; IL-2, n=19) on CD8⁺ T-cells in TIGIT⁺ CD8⁺ T-cells high/low infiltration group. (D) Expression of cytotoxicity activation molecules (GZMB, n=19; CD107a, n=18; PRF-1, n=8) on CD8⁺ T-cells in TIGIT⁺ CD8⁺ T-cells high/low infiltration group. (E) Correlation between TIGIT⁺ CD8⁺ T-cells among CD45⁺ cells and IL-10⁺ CD8⁺ T-cells among CD45⁺ cells based on the results of flow cytometry. (F) Correlation between TIGIT⁺ CD8⁺ T-cells and IL-10⁺ cells based on the evaluation of immunohistochemistry staining. *P<0.05, **P<0.01 by Mann-Whitney U test. PD-1, program death-1; CTLA-4, cytotoxic T lymphocyte-associated antigen-4; IFN, interferon; IL, interleukin; GZMB, granzyme B; ns, no significance; TIGIT, T-cell immunoglobulin and ITIM domain.