Table 1:
Characteristics of UK Biobank participants at the baseline visit based on the presence or absence of IDH, both by ESC/NICE and ACC/AHA definitions *
| Participant Characteristics | Normotension by ESC/NICE Definition N=142225 |
IDH by ESC/NICE Definition N=9606 |
P-value† | Normotension by ACC/AHA Definition N=67254 |
IDH by ACC/AHA Definition N=21872 |
P-value‡ |
|---|---|---|---|---|---|---|
| Percentage % | 93.7 | 6.3 | 75.5 | 24.5 | ||
| Male (%) | 39.0 | 49.9 | <0.001 | 31.8 | 39.4 | <0.001 |
| Age (Years) | 54.66 (8.08) | 53.20 (7.70) | <0.001 | 53.80 (8.08) | 52.73 (7.63) | <0.001 |
| Townsend Deprivation Index | -1.54 (2.93) | -1.30 (3.02) | <0.001 | −1.50 (2.95) | −1.37 (3.00) | <0.001 |
| Qualification | <0.001 | <0.001 | ||||
| O levels, CSE or equivalent | 17.6 | 18.3 | 17.5 | 18.6 | ||
| A levels, professional or equivalent | 33.7 | 36.9 | 32.9 | 35.1 | ||
| Degree | 35.8 | 31.7 | 38.3 | 35.0 | ||
| None | 12.9 | 13.0 | 11.3 | 11.4 | ||
| Smoking Status | 0.034 | 0.249 | ||||
| Never | 56.5 | 55.1 | 57.2 | 56.6 | ||
| Previous | 32.5 | 33.5 | 31.3 | 31.8 | ||
| Current | 11.0 | 11.4 | 11.5 | 11.6 | ||
| Alcohol consumption (%) | 0.043 | <0.001 | ||||
| Never | 3.0 | 2.7 | 3.1 | 2.6 | ||
| Previous | 3.6 | 3.3 | 4.0 | 3.5 | ||
| Current | 93.3 | 93.9 | 92.9 | 93.9 | ||
| Antihypertensive (%) | <0.001 | <0.001 | ||||
| Yes | 0.001 | 0.0 | 0.007 | 0.01 | ||
| No | 69.3 | 73.3 | 68.0 | 71.0 | ||
| NA category | 30.6 | 26.7 | 31.9 | 29.0 | ||
| SBP (mmHg) | 123.19 (9.29) | 131.96 (5.19) | <0.001 | 116.34 (7.51) | 122.59 (4.63) | <0.001 |
| Pulse pressure (mmHg) | 47.44 (7.62) | 41.16 (5.18) | <0.001 | 45.22 (6.68) | 40.23 (4.94) | <0.001 |
| BMI (kg/m2) | 26.39(4.43) | 29.62 (5.44) | <0.001 | 25.45 (4.08) | 27.83 (4.98) | <0.001 |
| Diabetes (%) | 3.7 | 4.5 | <0.001 | 2074 (3.1) | 713 (3.3) | 0.199 |
| Direct LDL (mmol/L) | 3.51 (0.84) | 3.67 (0.86) | <0.001 | 3.44 (0.82) | 3.59 (0.84) | <0.001 |
| HDL Cholesterol (mmol/L) | 1.48 (0.38) | 1.37 (0.36) | <0.001 | 1.51 (0.38) | 1.43 (0.37) | <0.001 |
| Triglycerides (mmol/L) | 1.60 (0.94) | 1.92 (1.10) | <0.001 | 1.47 (0.86) | 1.70 (0.99) | <0.001 |
| eGFR (ml/min/1.73m2) | 9.72 (10.30) | 9.08 (9.96) | <0.001 | 10.05 (10.6) | 9.42 (10.37) | <0.001 |
*
Values are either % or mean (standard deviation)
†
P value comparing those with normotension (systolic BP <140 mmHg and diastolic BP <90 mmHg) to those with IDH (systolic BP <140 mmHg and diastolic BP ≥90 mmHg)
‡
P value comparing those with normotension (systolic BP <130 mmHg and diastolic BP <80 mmHg) to those with IDH (systolic BP <130 mmHg and diastolic BP ≥80 mmHg)