Table 1.
The 20 most frequent mutation events observed in sequenced SARS-CoV-2 genomes.
| Genomic coordinate | Effect on protein/UTR | Nr of samples | Class | Genomic region |
|---|---|---|---|---|
| A23403G | S:D614G | 36,500 | aa-changing SNP | Spike protein |
| C14408T | NSP12b:P314L | 36,444 | aa-changing SNP | Non-structural protein 12, post-ribosomal frameshift (RNA-dependent RNA polymerase) |
| C3037T | NSP3:F106F | 36,384 | silent SNP | Non-structural protein 3 (predicted phosphoesterase) |
| C241T | 5′UTR:241 | 36,007 | 5′UTR SNP | 5′ UnTranslated Region |
| GGG28881AAC | N:RG203KR | 14,095 | aa-changing SNP triplet | Nucleocapsid protein |
| G25563T | ORF3a:Q57H | 10,929 | aa-changing SNP | ORF3a protein |
| C1059T | NSP2:T85I | 8,451 | aa-changing SNP | Non-structural protein 2 |
| G11083T | NSP6:L37F | 5,507 | aa-changing SNP | Non-structural protein 6 (transmembrane protein) |
| C14805T | NSP12b:Y446Y | 4,505 | silent SNP | Non-structural protein 12, post-ribosomal frameshift (RNA-dependent RNA polymerase) |
| T28144C | ORF8:L84S | 3,804 | aa-changing SNP | ORF8 protein |
| G26144T | ORF3a:G251V | 3,792 | aa-changing SNP | ORF3a protein |
| C8782T | NSP4:S76S | 3,743 | silent SNP | Non-structural protein 4 |
| A20268G | NSP15:L216L | 2,479 | silent SNP | Non-structural protein 15 (endoRNAse) |
| C18060T | NSP14:L7L | 1,813 | silent SNP | Non-structural protein 14 (3′-5′ exonuclease) |
| C23731T | S:T723T | 1,799 | silent SNP | Spike protein |
| G10097A | NSP5:G15S | 1798 | aa-changing SNP | Non-structural protein 5 (protease) |
| A17858G | NSP13:Y541C | 1,780 | aa-changing SNP | Non-structural protein 13 |
| C17747T | NSP13:P504L | 1,736 | aa-changing SNP | Non-structural protein 13 |
| C2558T | NSP2:P585S | 1,701 | aa-changing SNP | Non-structural protein 2 |
| A2480G | NSP2:I559V | 1,615 | aa-changing SNP | Non-structural protein 2 |
The acronym “aa” stands for “amino acid”.