Extended Data Fig. 10 |. The spectrum of plasmablast-to-granulocyte phenotype is present in patients experiencing ARDS and this putative transdifferentiation is likely unrelated to transcriptional dynamics of canonical neutrophils.
a, UMAP embedding of plasmablasts and activated granulocytes faceted by COVID-19 sample. n = 3,187 cells are plotted from n = 14 biologically independent samples. b-c, UMAP embeddings of plasmablasts, activated granulocytes, and canonical neutrophils overlaid with RNA velocity stream (b) or velocity grid (c). n = 3,911 cells are plotted from n = 14 biologically independent samples.