FIGURE 2.
Molecular structure of Protocadherin family members. cPcdhs: α-, β-, and γ-Pcdhs present 6 extracellular cadherin (EC) repeats (ellipses) in their extracellular domain (ECD), a transmembrane domain (TM), and a conserved intracellular domain (ICD) (with the exception of β-Pcdhs, which possess a truncated ICD). The variable cytoplasmic domain (VCD) motif has been observed in some γ-Pcdhs and α-Pcdhs. ncPcdhs (δ0-Pcdhs, δ1-Pcdhs, and δ2-Pcdhs) represent transmembrane proteins with either 7 (for δ0-Pcdhs, δ1-Pcdhs) or 6 (for δ2-Pcdhs) EC repeats. Within their ICDs, δ1-Pcdhs have three conserved motifs (CM), while δ2-Pcdhs have two CMs. Moreover, δ2- and a few α-Pcdhs harbor a WAVE interacting receptor sequence (WIRS).