Table 2.
Univariable and multivariable Cox regression analyses according to the Amsterdam model in patients with resected pancreatic cancer diagnosed between 2005 and 2016
| Clinicopathological parameter | Median OS, months | 5-year survival (%) | Univariable analysis HR (95% CI) |
Multivariable analysis HR (95% CI)b |
p valuec |
|---|---|---|---|---|---|
| Age (each incremental year) | – | – | 1.01 (1.00–1.01) | 1.00 (1.00–1.01) | 0.04 |
| Tumor differentiation grade | |||||
| Well-differentiated | 27 | 27 | 1.00 (reference) | 1.00 (reference) | |
| Moderately differentiated | 19 | 16 | 1.41 (1.21–1.65) | 1.27 (1.11–1.46) | 0.001 |
| Poorly or undifferentiated | 14 | 12 | 1.94 (1.66–2.28) | 1.74 (1.51–2.00) | < 0.001 |
| Lymph node ratioa | |||||
| 0 (lymph node-negative) | 25 | 28 | 1.00 reference | 1.00 (reference) | |
| > 0 and ≤ 0.18 | 18 | 13 | 1.44 (1.27–1.63) | 1.47 (1.31–1.64) | < 0.001 |
| > 0.18 | 15 | 8 | 1.86 (1.67–2.07) | 1.94 (1.76–2.14) | < 0.001 |
| Resection margin | |||||
| R0 | 20 | 19 | 1.00 (reference) | 1.00 (reference) | |
| R1/R2 | 14 | 8 | 1.57 (1.44–1.70) | 1.44 (1.33–1.57) | < 0.001 |
| Adjuvant chemotherapy | |||||
| Yes | 21 | 20 | 1.00 (reference) | 1.00 (reference) | |
| No | 14 | 11 | 1.52 (1.41–1.65) | 1.64 (1.51–1.79) | < 0.001 |
Data after multiple imputation were used
OS overall survival, HR hazard ratio, CI confidence interval
aLymph node ratio is the number of positive lymph nodes divided by the total number of lymph nodes harvested
bHazard ratios and 95% CIs from the Cox LASSO model are presented
cp values of multivariable analyses are shown