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THP-1 expression of co-stimulatory molecules A) CD80 and B) HLA-DR following stimulation with human serum albumin (HSA), HSA modified with malondialdehyde-acetaldehyde (HSA-MAA), citrullinated HSA (HSA-Cit), or co-modified HSA (HSA-MAA-Cit) in adherent and suspended cells. (*) Significant difference (p <0.05) vs. all other antigen groups. (+) p <0.05 vs. HSA in adherent cells and p <0.05 vs. HSA and HSA-MAA in suspension (each experiment replicated 3 times).
