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. 2020 Apr 17;117(18):10024–10034. doi: 10.1073/pnas.1917573117

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Copyright © 2020 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 6. — Changes in sleep due to age are due to both sleep pressure and depth. (A) Daily cycle of percentage (%) of Time Asleep, P(Doze), and P(Wake) for wild-type (CS) flies at 1, 3, 5, or 7+ wk post eclosion. (B–D) Comparison of time asleep (B), number (#) of sleep episodes (C), P(Doze) (D), and P(Wake) (E) across aging during daytime (open circles) and nighttime (filled circles). Error bars are SEM. (F) The population means of the aging fly cohorts are overlaid on the in silico-predicted sleep heatmap. Daytime values: white outline; nighttime values: black outline. n.s., no significant difference; *P < 0.05; ***P < 0.0005.