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. Author manuscript; available in PMC: 2020 May 7.
Published in final edited form as: Circ Cardiovasc Genet. 2015 Jan 30;8(2):270–283. doi: 10.1161/CIRCGENETICS.114.000767

Table 4 –

Significant differential changes in gene expression in Responders vs. Nonresponders compared with known gene regulatory pathways

Concordance with regulatory pathways
 Verification
Gene name Δ, R vs. NR *Adult/
Fetal		 †Inverse
β1-AR stimulation		 ‡THR GAPDH+18S Affymetrix
ADRB1 ↑ + + + ✓ NS
ADRB2 ↑ ? + + ✓ ✓
ADRA1A ↑ + + + ✓ NS
MYH6 ↑ + + + ✓ ✓
MYL3 ↑ + + X ✓ ✓
NPPA ↓ + + + ✓ ✓
NPPB ↓ + + + ✓ ✓
ATP2A2 ↑ + + + ✓ NS
PLN ↑ + + − ✓ ✓
RYR2 ↑ + + + ✓ ✓
CPT1B ↑ + + + ✓ NS
PDHX ↑ ? ? ? ✓ NS
PFKM ↑ + + + ✓ ✓
MYH6/MYH7 ↑ + + + ✓ ✓
ACTC1/ACTA1 ↑ + + + NS ✓
‡

Changes in gene expression concordant with thyroid hormone stimulation or TR-α1 expression.7

†

Directionally opposite regulation from that produced by β1-AR stimulation5,36 or transgenic cardiac overexpression;6

*

+=Concordant with pathway; −=Discordant with pathway; ?=Unknown if regulated by pathway; X=not regulated by pathway; ✓=Concordant, significant; NS=Concordant, not significant ; Δ=Directional change; R=Responder; NR=Nonresponder; THR=Thyroid hormone receptor. Decreased expression of genes expressed at higher levels in embryonic development (“fetal” genes) or increased expression of genes expressed at higher levels in the adult than in embryonic development (“adult” genes);