Figure 4.
Changes of hippocampal membrane monocarboxylate transporters 1 (MCT1), MCT4 and MCT2 protein levels after 6 months of ketamine administration in different groups as revealed by Western blot. (A,B) Significant decline of MCT1 expression levels were seen in ket2 group comparing with ket1 group and control group respectively (F(2,27) = 3.405, #p < 0.05 and F(2,27) = 5.823, **p < 0.01, respectively). (C,D) Significant decline of MCT4 expression levels were seen in ket2 group comparing with control group and ket1 group respectively (F(2,27) = 3.442, *p < 0.05 and F(2,27) = 5.604, ##p < 0.01, respectively). Obviously increase of MCT4 expression levels were seen in ket1 group comparing with control group (F(2,27) = 3.482, *p < 0.05). (E,F) Significant increase of MCT2 expression levels were seen in ket2 and ket1 group comparing with control group respectively (F(2,27) = 6.104, **p < 0.01; F(2,27) = 3.707, *p < 0.05, respectively; saline n = 10, ket1 n = 10, ket2 n = 10).