Fig. 4.
Alignment of predicted VP1 amino acid sequences HRV-QPM and HRV-A (HRV-1A, 16, 82 and 98) and HRV-B (HRV-5, 14,2 and 42) species. Numbering based on the HRV-QPM sequence (EF186077). The 25 residues of the pleconaril binding pocket are arrowed (majority HRV-B amino acid sequence listed below each arrow, Ledford et al., 2005). Two regions, indicated by overhead lines, appeared to be absent in HRV-QPM when compared with all other HRV VP1 sequences on GenBank (representative data shown here). Two residues predicted by Ledford to convey complete antiviral resistance to natural HRV-B strains (e.g. in HRV-5 and 14) are indicated by stars. Residues identical to HRV-QPM are indicated by dots. The absence of a residue is indicated by a dash.