Extended Data Fig. 6. ETC-168 treatment restores cognitive rigidity in Fmr1KO mice.
a, Schematics of the Place-independent cue discrimination and reversal task. This task was chosen given that phenotypes in cognitive rigidity tasks have been replicated in multiple studies on this model. b, Mean consecutive correct responses plotted for Fmr1WT/y and Fmr1KO/y mice. c, Treatment schedule of Fmr1WT/y and Fmr1KO /y mice. Animals were treated daily with vehicle during the learning phase and with 5 mg/kg ETC-168 during the reversal phase 2 hours before the start of the test. d, Mean consecutive correct responses plotted for vehicle treated Fmr1WT /y and vehicle or ETC-168 Fmr1KO/y mice. Numbers in brackets indicate mice. Error bars report s.e.m. RM two-way ANOVA followed by Bonferrroni’s post-hoc test for b, d. See Supplementary information for additional statistics.