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. 2020 Mar 25;11:539. doi: 10.3389/fimmu.2020.00539

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Copyright © 2020 Wang and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysregulated miRNAs and their targets in myocarditis. Dysregulated intracellular miRNAs in myocarditis are further and roughly classified into myomiRs, cardiotropic viral infection-related miRNAs, immune status-related miRNAs, cardiotropic viral infection and immune status-related miRNAs, fibrosis-related miRNAs, and miscellaneous miRNAs. Most of these miRNAs result in the aggravation of myocarditis, while others result in the attenuation of myocarditis. Increased or decreased levels of circulating miRNAs can be detected in plasma of patients with myocarditis.