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. 2018 Dec 10;17(3):181–192. doi: 10.1038/s41579-018-0118-9

Fig. 3. Phylogenetic relationships in the Coronavirinae subfamily.

Fig. 3

The highly human-pathogenic coronaviruses belong to the subfamily Coronavirinae from the family Coronaviridae. The viruses in this subfamily group into four genera (prototype or representative strains shown): Alphacoronavirus (purple), Betacoronavirus (pink), Gammacoronavirus (green) and Deltacoronavirus (blue). Classic subgroup clusters are labelled 1a and 1b for the alphacoronaviruses and 2a–2d for the betacoronaviruses. The tree is based on published trees of Coronavirinae25,136 and reconstructed with sequences of the complete RNA-dependent RNA polymerase-coding region of the representative coronaviruses (maximum likelihood method under the GTR + I + Γ model of nucleotide substitution as implemented in PhyML, version 3.1 (ref.137)). Only nodes with bootstrap support above 70% are shown. IBV, infectious bronchitis virus; MERS-CoV, Middle East respiratory syndrome coronavirus; MHV, mouse hepatitis virus; PEDV, porcine enteric diarrhoea virus; SARS-CoV, severe acute respiratory syndrome coronavirus; SARSr-CoV, SARS-related coronavirus.