Table 2.
Severe sepsis
| Severe sepsis definition = sepsis-induced tissue hypoperfusion or organ dysfunction (any of the following thought to be due to the infection) |
| Sepsis-induced hypotension |
| Lactate above upper limits laboratory normal |
| Urine output <0.5 mL kg−1 h−1 for more than 2 h despite adequate fluid resuscitation |
| Acute lung injury with Pao 2/Fio 2 <250 in the absence of pneumonia as infection source |
| Acute lung injury with Pao 2/Fio 2 <200 in the presence of pneumonia as infection source |
| Creatinine >2.0 mg/dL (176.8 μmol/L) |
| Bilirubin >2 mg/dL (34.2 μmol/L) |
| Platelet count <100,000 μL |
| Coagulopathy (international normalized ratio >1.5) |
Adapted from [6]