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. Author manuscript; available in PMC: 2020 Feb 28.
Published in final edited form as: Nat Struct Mol Biol. 2019 Jun 24;26(7):619–627. doi: 10.1038/s41594-019-0248-4

Figure 3. Calculated solvation energy maps for TDP-43 fibrils based on atomic solvation parameters.

Figure 3

Solvation energy maps of SegA-sym (left) and SegB A315E (right). Residues are colored from unfavorable (blue, −2.5 kcal/mol) to favorable stabilization energy (red, 2.5 kcal/mol). Notice that both the dagger-shaped fold (SegA-sym) and the R-shaped fold (SegB A315E) show stable cores.