Table 1.
Enriched canonical pathways of differentially expressed genes.
| Canonical pathway | z-score | p-value | Associated gene number |
|---|---|---|---|
| NF-κB signaling | 3.207 | 2.40E-05 | 14 |
| Acute phase response signaling | 2.887 | 2.24E-05 | 14 |
| Role of IL17F in allergic inflammatory airway diseases | 2.449 | 4.07E-05 | 7 |
| Toll-like receptor signaling | 1.342 | 3.09E-05 | 9 |
| TNFR2 signaling | 1.000 | 3.09E-05 | 6 |
| NRF2-mediated oxidative stress response | −1.069 | 7.41E-06 | 32 |
Ingenuity pathway analysis (IPA) of the score for the likelihood that genes belonging to a specific canonical pathway category were different after 8 h of LPS + IFNγ stimulation of Nos2−/− and WT BMDMs. Positive or negative z-score value indicates that a function is predicted to be increased or decreased in Nos2−/− relative to WT activated cells. The significance of canonical pathways was determined by IPA’s default threshold [–log (p-value) > 1.3] (p < 0.05). The associated gene number represents the number of differentially expressed genes involved in the respective canonical pathway.