Fig. 3.
SNAI1 and ZEB1 mRNA expression in melanoma. a Plot shows the relative expression of SNAI1 and ZEB1 in two paired primary (red dashed line) and metastatic melanoma samples from the same patient (TCGA-ER-A2NF) from GDC database. b Bar plot shows the relative expression of SNAI1 and ZEB1 in seven metastatic breast cancer samples normalized over the corresponding primary tumors from the same patients. Dashed red line indicates the normalized level of expression in primary tumor samples. ZEB1 fold changes are less than one in all the samples, showing that its expression is reduced in metastatic tumors, coherently with what observed in melanoma. Data were downloaded from GDC database as described in materials and methods section. Correspondence between x-axis label and GDC cases: 1-TCGA-BH-A1ES, 2-TCGA-AC-A6IX, 3-TCGA-BH-A1FE, 4-TCGA-E2-A15K, 5-TCGA-E2-A15A, 6-TCGA-E2-A15E, 7-TCGA-BH-A18V