Table 3.
Genetic ancestry for type 1 diabetes patients stratified according to autoimmunity
| Chromosomal region | Ancestry | T1AD, median (IQR) | T1BD, median (IQR) | P value1 |
| Overall AIMs | EUR | 61.92 (53.57-70.89) | 59.79 (49.70-68.03) | 0.333 |
| NAT | 27.07 (20.82-33.48) | 29.16 (21.57-37.06) | 0.312 | |
| AFR | 10.19 (2.88-16.01) | 11.54 (5.55-17.80) | 0.344 | |
| Chr2_EFR3B | EUR | 60.28 (36.24-83.66) | 59.79 (32.34-80.01) | 0.551 |
| NAT | 25.16 (0.01-51.24) | 21.92 (0.01-45.95) | 0.979 | |
| AFR | 4.53 (0.01-23.32 | 14.41 (0.01-27.36) | 0.119 | |
| Chr2_CTLA4 | EUR | 53.34 (16.82-70.53) | 41.16 (16.62-60.86) | 0.231 |
| NAT | 26.28 (4.55-41.31) | 32.69 (9.35-50.25) | 0.343 | |
| AFR | 20.54 (0.01-41.73) | 19.47 (0.01-42.52) | 0.764 | |
| Chr2_RNASEH1 | EUR | 58.96 (37.72-73.87) | 47.50 (26.38-78.10) | 0.506 |
| NAT | 26.92 (14.19-45.66) | 31.59 (0.01-51.98) | 0.885 | |
| AFR | 6.85 (0.01-28.24) | 11.71 (0.01-27.86) | 0.657 | |
| Chr2_IFIH1 | EUR | 41.90 (0.01-76.72) | 42.42 (0.01-67.93) | 0.708 |
| NAT | 32.56 (0.01-55.56) | 27.39 (2.01-56.89) | 0.985 | |
| AFR | 14.99 (0.01-42.31) | 0.01 (0.01-36.48) | 0.654 | |
| Chr5_IL7R | EUR | 13.27 (1.02-43.73) | 9.19 (1.77-33.67) | 0.555 |
| NAT | 50.94 (38.08-98.60) | 53.12 (31.82-95.13) | 0.984 | |
| AFR | 14.68 (3.17-33.94) | 17.98 (2.75-41.01) | 0.634 | |
| Chr6_MHC | EUR | 52.31 (37.26-72.43) | 45.73 (19.25-67.03) | 0.087 |
| NAT | 20.32 (7.12-37.06) | 31.88 (17.65-44.62) | 0.019 | |
| AFR | 18.50 (3.21-36.04) | 21.13 (0.53-36.56) | 0.905 | |
| Chr10_NRP1 | EUR | 63.32 (28.61-69.09) | 63.31 (6.89-63.32) | 0.092 |
| NAT | 36.67 (7.93-36.67) | 36.67 (7.93-59.79) | 0.282 | |
| AFR | 0.25 (1e-05-26.0) | 0.52 (1e-05-37.80) | 0.848 |
1
Mann-Whitney U test. AIMs: Ancestry informative markers; IQR: Interquartile range; Chr: Chromosome; EUR: European; NAT: Native American; AFR: African; T1AD: Autoimmune type 1 diabetes; T1BD: Idiopathic type 1 diabetes.