Table 4.
General and specific role of lncRNAs with differential expression between different cytogenetic risk categories in AML.
| lncRNAs | Function in other malignancies | Function in AML | References |
|---|---|---|---|
| DANCR | Oncogenic role, promotes migration, invasion, proliferation | No record found | (129, 130) |
| PRDM16-DT | Tumor suppressor role | Reported to be overexpressed in Flt3-itd mutation for AML | (102, 131, 132) |
| SNHG6 | Oncogenic role, stimulates cancer cell growth, migration, invasion, cell autophagy | No record found | (133–135) |
| OIP5-AS1 | Oncogenic role, promotes proliferation, maintenance of cell stemness | No record found | (136–138) |
| SNHG16 | Oncogenic role, stimulates proliferation, migration, and invasion | No record found | (139–141) |
| JPX | Tumor suppressor role | No record found | (142) |
| FTX | Oncogenic role, stimulates glycolisis, malignant cell proliferation, invasion and migration, poor prognostic | Contributes to MDR in AML-M5 | (143–145) |
| KCNQ1OT1 | Oncogenic role, promotes malignant cell proliferation, chemoresistance | No record found | (146, 147) |
| Tumor suppressor role, inhibits malignant cell proliferation | (148) | ||
| TP73-AS1 | Oncogenic role, promotes malignant cell proliferation, invasion and migration, poor prognostic | No record found | (149, 150) |
| GAS5 | Tumor suppressor role, inhibits cell proliferation, invasion, and promotes apoptosis | Mutations in this gene leads to worse prognostic | (151, 152) |
Results from literature review.