Fig. 1.
Opioid withdrawal enhances GABAergic eIPSCs, and morphine is more efficacious in neurons from dependent animals.A, Averaged eIPSC traces elicited from single neurons from vehicle-treated (Vehicle) and dependent animals (Dependent) maintained in morphine (5 μm) before and during superfusion of naloxone (1 μm).B, eIPSC traces from single neurons from vehicle-treated (Vehicle) or dependent animals (Dependent) during spontaneous withdrawal (no morphine for >1 hr) before (control), in the presence of superfused morphine (10 μm; morphine), and subsequently during cosuperfusion of naloxone (1 μmnaloxone; trace overlaid oncontrol trace).