Fig. 5.
Pharmacological block of the sustained current induced by BAPTA treatment. a–c, Application of 100 μm DHSM (a), 300 μmamiloride (b), or 1 mm gadolinium ions (c) leads to a total and reversible block of the tonic current induced by the treatment with 5 mm BAPTA.Horizontal bars indicate application of DHSM, amiloride, and Gd3+, respectively. d, DHSM blocks the tonic current at negative holding potentials in a voltage-dependent manner. These experiments indicate that the tonic current flows through permanently opened transduction channels after loss of tip links.