Fig. 5.
Supraspinal injection sites. One side is depicted for each bilateral injection on drawings adapted from the atlas ofPaxinos and Watson (1986). A, Nucleus accumbens injection sites, left (flup), flupentixol injection sites; right (nlx), naloxone methiodide injection sites. ▴, ▵, Onsite injection before capsaicin administration in anesthetized or awake animals, respectively; ▾, onsite injection before hindpaw immersion in 50°C water bath anesthetized or awake animals, respectively (sites for naloxone methiodide in anesthetized animals not shown); ▪, off-site injection before intraplantar capsaicin administration; ●, injection given in the absence of noxious stimulation. B, Rostroventral medulla injection sites. ▴, Naloxone methiodide before intraplantar capsaicin administration; ●, naloxone methiodide given before intra-PAG DAMGO administration; ♦, muscimol (single injections) given before intraplantar capsaicin administration; ⋄, without noxious stimulation.