Fig. 4.
CTZ increased Bergmann glia patch responses to glutamate in a dose-dependent manner. Responses of an outside-out patch to 300 (A) and 3000 (B) μmglutamate (GLU) under control conditions (thin lines) and in the presence of 200 μmCTZ (thick lines). The 300 μm response was increased 9.6-fold by CTZ, whereas the 3000 μm response was only increased 2.5-fold. The responses are averages of 20–40 traces. To account for a small amount of rundown, the conditions were repeated two to three times interleaving the various conditions. The patch was held at −80 mV. The applications were 10 msec long and separated by 10 sec.