Fig. 5.
Reduction of different striatal interneuron subtypes in E18.5 Nkx2.1−/− fetuses (A) and P0Mash1−/− (B) and Dlx1/2−/−(C) newborns. Histograms show averages ± SEM of the numbers of specific types of striatal interneurons. InA and B the cells were counted in two defined sections of the striatum (rostral and caudal) in three independent experiments in each case. Total represents the collective consideration of both rostral and caudal sections. InC the cells were counted in a single striatal level in three independent experiments. In Control* we have taken into account the fourfold reduction in striatal surface area in theDlx1/2 mutants (see Materials and Methods) by dividing the number of striatal interneurons in the wild-type striatum by four.BMC, Basal magnocellular complex.