Table 1.
Effect of repeated administration of amphetamine on neuronal nitric oxide synthase immunoreactivity in the rat prefrontal cortex and nucleus accumbens
| Number of nitric oxide synthase-positive neurons | ||
|---|---|---|
| Region | Vehicle-treated (n = 4) | Amphetamine-treated (n = 4) |
| Prefrontal cortex | 209 ± 24 | 117 ± 12; *p < 0.05 |
| Nucleus accumbens | 162 ± 16 | 54 ± 10; *p < 0.005 |
The number of nitric oxide synthase-positive neurons was counted in 60-μm-thick sections in a designated area (1 × 1 mm) within these brain regions (at the M-L coordinates: 1.4 mm and 2.0 mm lateral to the sagittal suture; Paxinos and Watson, 1986) in rats at 14 d after withdrawal from amphetamine. *Student's t test compared to vehicle-treated control.