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PPARγ agonists prevent differentiation of THP-1 monocytes into macrophages. THP-1 monocytes were incubated with vehicle only (control; DMSO and ethanol; A) or induced to differentiate into macrophages by treatment with 100 nm TPA for 48 hr (B, D, F, H) in the absence (A, B) or presence of 10 μm 15d-PGJ2 (C, D), 50 μmDHA (E, F), or 50 μm troglitazone (trog.; G, H).
