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. 2000 Jul 15;20(14):5191–5199. doi: 10.1523/JNEUROSCI.20-14-05191.2000

Table 1.

Outward K+ currents in wild-type and transfected SCG neurons1-a

Phenotype Wild type Kv4.2W362F Kv4.2
Type I Type II Type III A B C Type I Type II
Peak current density 252  ± 20 259  ± 22 211  ± 18 162  ± 21 289  ± 31 244  ± 35 249  ± 27 291  ± 37
IAf density (pA/pF) 81  ± 11 111  ± 21 64  ± 20 127  ± 91-213 136  ± 161-213
τ (msec) 121  ± 14 95  ± 8 190  ± 18 87  ± 10 70  ± 8
IAs density (pA/pF) 45  ± 3 67  ± 15 57  ± 21
τ (msec) 480  ± 21 490  ± 31 472  ± 8
IK density (pA/pF) 108  ± 12 64  ± 9* 136  ± 11 111  ± 22 157  ± 251-160 115  ± 7 78  ± 171-214 67  ± 2
τ (msec) 2560  ± 187 2800  ± 193 2200  ± 176 2050  ± 235 2473  ± 254 2368  ± 197 2126  ± 518 2151  ± 195
ISS density (pA/pF) 74  ± 5 45  ± 5* 79  ± 6 65  ± 9 72  ± 15 68  ± 15 40  ± 61-214 38  ± 17
n 30 9 4 18 7 6 11 5
*

IK andISS densities are significantly (p < 0.005) lower in wild-type Type II than in either wild-type Type I or III cells.

F1-160: IKdensity is significantly (p < 0.002) higher in Kv4.2W362F-expressing cells than in wild-type Type II cells.

F1-213: IAf density is significantly (p < 0.04) greater in Kv4.2-expressing cells than in wild-type Type I or II cells.

F1-214: IK andISS densities are also significantly (p < 0.005) lower in Kv4.2-expressing cells than in wild-type Type I cells (Table 1).

F1-a

All values are mean ± SEM; current densities determined at +50 mV; n = number of cells.