Fig. 2.
DRG neurons exhibited complex patterns of responsiveness to chemokines in a fura-2-based calcium-imaging experiment. This figure shows examples of responsiveness of individual DRG neurons to combinations of chemokines. Note that chemokine-responsive neurons were also frequently responsive to known excitants of nociceptive neurons such as bradykinin, capsaicin, or ATP. However, this was not inevitably the case (e.g., compareB, C). Concentrations of molecules that were applied in these studies were eotaxin (E; 50 nm), MDC (50 nm), TARC (50 nm), MCP-1 (50 nm), MIP-1β (50 nm), IP-10 (50 nm), SLC (50 nm), BCA (50 nm), VMIP-I (v-I, 100 nm), VMIP-II (v-II, 100 nm), VMIP-III (v-III, 100 nm), bradykinin (BK, 1 μm), capsaicin (Cap, 1 μm), and ATP (100 μm).