Table 2.
Cardiovascular measurements obtained in control (combined 1 month, n = 13; 2 month controls, n = 20), C2 hemisected (1 month, n = 8; 2 months, n = 15), DHT-only (n = 7), and DHT + C2 hemisected (n = 10) rats
| Control | C2hemisected | DHT | DHT + C2 hemisected | ||
|---|---|---|---|---|---|
| 1 Month | 2 Months | ||||
| Hypercapnia | |||||
| Arterial pH | 7.22 ± 0.03 | 7.22 ± 0.04 | 7.24 ± 0.02 | 7.21 ± 0.05 | 7.24 ± 0.03 |
| PaCO2 (mmHg) | 65 ± 6 | 62 ± 5 | 65 ± 3 | 67 ± 3 | 66 ± 5 |
| PaO2(mmHg) | 198 ± 19 | 182 ± 19 | 187 ± 15 | 185 ± 13 | 202 ± 7 |
| Mean ABP (mmHg) | 117 ± 24 | 119 ± 17 | 128 ± 17 | 130 ± 13 | 114 ± 19 |
| Heart rate (min−1) | 433 ± 37 | 452 ± 32 | 452 ± 32 | 451 ± 30 | 430 ± 49 |
| Hypoxia | |||||
| Arterial pH | 7.38 ± 0.06 | 7.41 ± 0.10 | 7.37 ± 0.08 | 7.33 ± 0.08 | 7.34 ± 0.04 |
| PaCO2 (mmHg) | 35 ± 8 | 31 ± 6 | 37 ± 4 | 35 ± 4 | 37 ± 6 |
| PaO2 (mmHg) | 106 ± 22 | 30 ± 4 | 24 ± 6 | 25 ± 6 | 28 ± 7 |
| Mean ABP (mmHg) | 93 ± 32 | 85 ± 14 | 106 ± 27 | 107 ± 27 | 98 ± 28 |
| Heart rate (min−1) | 448 ± 38 | 449 ± 57 | 445 ± 47 | 457 ± 44 | 442 ± 39 |
Means ± SD.
Arterial blood gas measurements during hypercapnia obtained from control (n = 27), C2 hemisected (1 month,n = 8; 2 months, n = 10), DHT-only (n = 5), and DHT + C2 hemisected (n = 7) rats. Arterial blood gas measurements during hypoxia obtained from control (n = 33), C2hemisected (1 month, n = 8; 2 months, n= 6), DHT-only (n = 4), and DHT + C2hemisected (n = 4) rats.