Table 2.
Mean (SEM) of laminar cytochrome oxidase activity units (micromoles per minute per gram of tissue wet weight) in human postmortem posterior cingulate (area 23) and primary motor cortex (area 4) in AD patients and age-matched controls
| Posterior cingulate cortex | Primary motor cortex | |||||
|---|---|---|---|---|---|---|
| Control | AD | % Difference | Control | AD | % Difference | |
| Layer I | 85 (8) | 52 (3)2-160 | −39% | 86 (7) | 68 (4) | −21% |
| Layer II | 88 (7) | 60 (3)2-160 | −32% | 103 (7) | 84 (4) | −18% |
| Layer III | 95 (9) | 71 (4)* | −25% | 115 (6) | 100 (4) | −13% |
| Layer IV | 87 (8) | 66 (3)* | −24% | 102 (5) | 91 (6) | −11% |
| Layer V | 83 (7) | 63 (3)* | −24% | 95 (6) | 86 (5) | −9% |
| Layer VI | 73 (6) | 55 (3)* | −25% | 86 (6) | 76 (5) | −12% |
| Mean | 85 (7) | 61 (2)2-160 | −28% | 98 (6) | 84 (4) | −14% |
Significantly lower than control (
*
p < 0.05;
F2-160: p < 0.01; two-tailed Bonferroni-corrected).