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. 2001 Nov 15;21(22):8715–8721. doi: 10.1523/JNEUROSCI.21-22-08715.2001

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Fig. 6. — NiCl₂ reduces the peak amplitude of EPSCs evoked in CA3 pyramidal neurons by minimal stimulation of the mossy fibers. A, Ten individual traces of EPSCs recorded from a holding potential of −60 mV, in control conditions and in the presence of NiCl₂. Note decreased EPSC amplitudes during NiCl₂ application and increased number of response failures after the first pulse. In this experiment, failure rate increased from 18.7 to 58.7%. B, Average EPSCs from the same experiment (n = 56 in control andn = 32 during application of NiCl₂). C, Plot of EPSC1 (filled symbols) and EPSC2 (open symbols) amplitude versus time before, during (horizontal bar), and after application of NiCl₂. D–F, Mean values of the EPSC1 amplitude (D), failure rate (E), and paired-pulse facilitation ratio (F) before (white columns) and during (black columns) NiCl₂ application (n = 5). *p < 0.05.