. Author manuscript; available in PMC: 2020 Mar 15.

Published in final edited form as: Clin Cancer Res. 2019 Jun 12;25(18):5503–5512. doi: 10.1158/1078-0432.CCR-19-0104

Table 2:

Summary of all candidate predictive markers for OS in tumor, CD68 and CD45 compartment, log-rank (Mantel-Cox) test.

Predictive markers for OS

Tumor ROI	Cutpoint	Hazard Ratio	95% CI	p value	CD68+ ROI	Cutpoint	Hazard Ratio	95% CI	p value	CD45+ ROI	Cutpoint	Hazard Ratio	95% CI	p value
CD20	Median	0.2581	0.1128 to 0.5904	0.0019	PDL1	Low (1st and 2nd tertile) vs High (3rd tertile)	0.153	0.0651 to 0.3598	0.0032	MSH2	Low (1st and 2nd tertile) vs High (3rd tertile)	3.277	1.222 to 8.783	0.0035
HLADR	Median	0.2762	0.1212 to 0.6294	0.0035	CD8	Median	0.3377	0.1448 to 0.7876	0.0119	B2M	Median	0.28	0.11 to 0.67	0.0049
CD8	Median	0.3321	0.1455 to 0.7578	0.01	B2M	Median	0.34	0.14 to 0.80	0.0138	PMS2	Median	2.763	1.162 to 6.574	0.0211
IDO1	Low (1st and 2nd tertile) vs High (3rd tertile)	0.2392	0.1033 to 0.554	0.0117	CD3	Median	0.373	0.1609 to 0.8648	0.0243
B2M	Median	0.42	0.18 to 0.96	0.0429	CD4	Median	0.3741	0.1613 to 0.8672	0.0244
					PMS2	Median	2.466	1.067 to 5.699	0.0405
					MYC	Median	2.466	1.067 to 5.7	0.0407